:root{color-scheme:dark;--bg:#141c25;--panel:#1c2833;--panel-alt:#213035;--panel-deep:#10171f;--text:#f1f1e6;--muted:#b8cccb;--line:#34464b;--line-bright:#486067;--accent:#d7e7a8;--strong:#67d49b;--weak:#e8b85c;font-family:Arial,Helvetica,sans-serif}
*{box-sizing:border-box}body{margin:0;background:var(--bg);color:var(--text);min-height:100svh;font-size:15px;line-height:1.5}a{color:var(--accent);text-decoration:none;text-underline-offset:4px}a:hover{text-decoration:underline}button,input,select{font:inherit;color:inherit}button,a,input,select,[tabindex]{outline-offset:3px}:focus-visible{outline:3px solid var(--accent)}[hidden]{display:none!important}
.site-header,main,footer{width:min(1540px,calc(100% - 48px));margin-inline:auto}.site-header{display:flex;align-items:center;justify-content:space-between;gap:20px;min-height:86px;border-bottom:1px solid var(--line)}.brand{font:700 33px Georgia,'Times New Roman',serif;letter-spacing:-1px;color:var(--text);text-decoration:none;white-space:nowrap}.brand:hover{text-decoration:none}.brand span{font:400 13px Arial,Helvetica,sans-serif;letter-spacing:1.5px;margin-left:10px;color:var(--muted)}.site-header nav{display:flex;align-items:center;gap:24px;color:var(--muted);font-size:15px}.site-header nav a{color:var(--muted)}.site-header nav a:hover{color:var(--text)}footer{border-top:1px solid var(--line);display:flex;justify-content:space-between;align-items:center;gap:20px;padding-block:24px;margin-top:44px;font-size:14px;color:var(--muted)}
.gene-nav{display:flex;flex-wrap:wrap;gap:6px 20px;border-bottom:1px solid var(--line);padding:15px 0;font-size:12.5px}.gene-nav a{color:var(--muted);padding:3px 0}.gene-nav [aria-current]{color:var(--accent);box-shadow:0 2px var(--accent)}.page-top{padding-block:26px 22px;border-bottom:1px solid var(--line);margin-bottom:22px}.page-top h1{font:600 clamp(26px,2.5vw,35px)/1.2 Georgia,serif;margin:0 0 8px}.lead{color:var(--muted);font-size:15px;max-width:960px;margin:0}.panel{background:var(--panel);border:1px solid var(--line);border-radius:8px;padding:20px;margin-bottom:20px;min-width:0}.panel-header{display:flex;justify-content:space-between;align-items:flex-start;flex-wrap:wrap;gap:12px;margin-bottom:16px}h2{font:600 22px/1.25 Georgia,serif;margin:0 0 6px}h3{font:600 18px/1.3 Georgia,serif;margin:0 0 10px}.panel-header p{margin:0;color:var(--muted);font-size:13px}.note,.source-note{font-size:12.5px;color:var(--muted);margin:14px 0 0;max-width:1180px}.source-note{margin-bottom:25px}.loading-panel{padding:24px}.loading-panel p{color:var(--muted);margin:5px 0}
.controls{display:grid;gap:12px}.classification-controls{grid-template-columns:1fr 1fr 1fr}.filter-grid{grid-template-columns:repeat(4,minmax(0,1fr))}.controls label,.compact-label{display:flex;flex-direction:column;gap:6px;font-size:12px;color:var(--muted);font-weight:600}.controls .check-field{flex-direction:row;align-items:center;gap:10px;padding-top:22px}.check-field input{width:18px;height:18px;accent-color:var(--accent)}.wide{grid-column:span 2}input,select{width:100%;min-width:0;background:var(--panel-deep);border:1px solid var(--line-bright);border-radius:5px;padding:10px 11px;font-size:13px;color:var(--text)}select{max-width:100%}button{background:var(--panel-alt);border:1px solid var(--line-bright);border-radius:5px;padding:8px 13px;font-size:12.5px;cursor:pointer}button:hover{border-color:var(--accent)}button:disabled{opacity:.45;cursor:default}.compact-label{min-width:155px}.compact-label select{padding:6px 8px}.summary-grid{display:grid;grid-template-columns:repeat(4,1fr);gap:12px;margin:0 0 20px}.summary-card{background:var(--panel-alt);border:1px solid var(--line);border-radius:7px;padding:15px 18px}.summary-card strong{display:block;color:var(--accent);font-size:27px;font-variant-numeric:tabular-nums}.summary-card span{color:var(--muted);font-size:12px}.summary-card small{display:block;color:var(--muted);font-size:11px;margin-top:4px}
.timeline-scroll{overflow:auto;padding:3px 3px 8px}.timeline{display:grid;grid-template-columns:repeat(var(--strata,8),minmax(135px,1fr));gap:8px;min-width:1060px;align-items:stretch}.stratum-card{background:var(--panel-deep);border:1px solid var(--line);border-top:4px solid var(--stratum);text-align:left;padding:12px 10px;display:flex;flex-direction:column;min-width:0;transition:border-color .15s}.stratum-card[aria-pressed=true]{outline:2px solid var(--accent);outline-offset:0;background:var(--panel-alt)}.stratum-card .era-label{min-height:48px;font-weight:700;font-size:12px;line-height:1.35}.era-groups{color:var(--muted);font-size:10px;min-height:48px;line-height:1.35;margin:5px 0}.era-bar-space{height:116px;display:flex;align-items:flex-end;border-bottom:1px solid var(--line);margin:5px 0 10px}.era-bar{width:100%;height:var(--height);background:var(--stratum);border-radius:3px 3px 0 0;opacity:.8}.era-count{font-size:24px;font-variant-numeric:tabular-nums}.era-stat{display:block;font-size:10.5px;color:var(--muted);margin-top:3px}
.table-scroll{overflow:auto;max-height:620px;border:1px solid var(--line);border-radius:6px;background:var(--panel-deep)}table{width:100%;border-collapse:collapse;font-size:12.5px}th,td{text-align:left;padding:10px 12px;border-bottom:1px solid var(--line);vertical-align:middle}thead th{position:sticky;top:0;background:var(--panel-alt);color:var(--muted);font-size:11px;z-index:1;font-weight:700}tbody tr:last-child td{border-bottom:0}tbody tr:hover{background:var(--panel-alt)}.matrix-scroll{max-height:480px}.matrix-scroll table{min-width:720px}.number{font-variant-numeric:tabular-nums;white-space:nowrap}.muted{color:var(--muted)}.table-btn{background:none;border:0;padding:0;text-align:left;color:var(--accent);font-weight:600;font-size:inherit}.table-btn:hover{text-decoration:underline}.gene-name{min-width:200px}.empty{padding:32px;text-align:center;color:var(--muted)}.pagination{display:flex;justify-content:center;align-items:center;gap:18px;margin-top:15px;font-size:12px;color:var(--muted)}.legend{display:inline-flex;align-items:center;gap:6px;font-size:11px;color:var(--muted);flex-wrap:wrap}.swatch{display:inline-block;width:10px;height:10px;border-radius:2px}.strong{background:var(--strong)}.weak{background:var(--weak)}.absent{background:#3c4c58}.stack{height:13px;display:flex;min-width:135px;width:100%;background:#3c4c58;border-radius:3px;overflow:hidden}.stack>span{height:100%;min-width:0}.stack .strong{background:var(--strong)}.stack .weak{background:var(--weak)}.stack-cell{min-width:190px}.breakdown-grid{display:grid;grid-template-columns:1fr 1fr;gap:20px}.breakdown-scroll{max-height:490px}.breakdown-scroll table{min-width:435px}.age-stack{width:130px;min-width:130px}.tiny{font-size:10.5px;color:var(--muted)}
dialog{width:min(1040px,calc(100% - 32px));max-height:calc(100svh - 40px);padding:0;color:var(--text);background:var(--panel);border:1px solid var(--line-bright);border-radius:9px}dialog::backdrop{background:rgba(9,14,19,.82)}.dialog-heading{display:flex;gap:16px;justify-content:space-between;align-items:flex-start;background:var(--panel-deep);padding:20px 22px;border-bottom:1px solid var(--line)}.dialog-heading p{margin:4px 0 0;color:var(--muted);font-size:13px}.dialog-body{padding:22px;display:grid;gap:20px;overflow-wrap:anywhere}.dialog-kpis{display:grid;grid-template-columns:repeat(3,1fr);gap:10px}.dialog-kpis>div,.annotation{background:var(--panel-deep);border:1px solid var(--line);border-radius:6px;padding:12px}.dialog-kpis strong{font-size:22px;color:var(--accent);display:block}.dialog-kpis span{font-size:12px;color:var(--muted)}.annotation p{margin:5px 0;font-size:13px}.dialog-columns{display:grid;grid-template-columns:1fr 1fr;gap:18px}.dialog-columns table{font-size:11px}.dialog-columns th,.dialog-columns td{padding:8px}.link-row{display:flex;gap:18px;flex-wrap:wrap;font-size:13px}.error{border-color:var(--weak)}
@media(max-width:1100px){.classification-controls{grid-template-columns:1fr 1fr}.filter-grid{grid-template-columns:repeat(3,minmax(0,1fr))}.breakdown-grid{grid-template-columns:1fr}.dialog-columns{grid-template-columns:1fr}.site-header nav{gap:15px}}
@media(max-width:780px){.site-header,main,footer{width:calc(100% - 28px)}.site-header{flex-wrap:wrap;justify-content:flex-start;gap:8px;padding:15px 0}.brand{font-size:29px}.site-header>nav{flex-wrap:wrap;gap:16px;width:100%;font-size:13px}.gene-nav{gap:8px 14px;font-size:11.5px}.panel{padding:15px}.classification-controls,.filter-grid{grid-template-columns:1fr 1fr}.controls .check-field{grid-column:1/-1;padding-top:4px}.summary-grid{grid-template-columns:1fr 1fr}.summary-card{padding:12px}.summary-card strong{font-size:24px}.dialog-kpis{grid-template-columns:1fr}.dialog-body{padding:15px}footer{align-items:flex-start;flex-direction:column;gap:8px;font-size:12px}.panel-header{gap:10px}h2{font-size:20px}}
@media(max-width:480px){.filter-grid,.classification-controls{grid-template-columns:1fr}.wide{grid-column:auto}.controls .check-field{grid-column:auto}.summary-card small{font-size:10px}.panel-header>button{width:100%}.dialog-heading{padding:15px}.dialog-heading h2{font-size:20px}.pagination{gap:10px}.pagination button{padding:7px 10px}}
@media(prefers-reduced-motion:reduce){*{transition:none!important;scroll-behavior:auto!important}}