:root {
  color-scheme: dark;
  --bg: #141c25;
  --panel: #1c2833;
  --panel-alt: #213035;
  --panel-deep: #10171f;
  --text: #f1f1e6;
  --muted: #b8cccb;
  --line: #34464b;
  --accent: #d7e7a8;
  --strong: #67d49b;
  --weak: #e8b85c;
  font-family: Arial, Helvetica, sans-serif;
}
* { box-sizing: border-box; }
body { margin: 0; background: var(--bg); color: var(--text); min-height: 100svh; font-size: 15px; line-height: 1.5; }
a { color: var(--accent); text-decoration: none; text-underline-offset: 4px; }
a:hover { text-decoration: underline; }
button, input, select { font: inherit; color: inherit; }
button { cursor: pointer; }
button:disabled { opacity: .4; cursor: default; }
button:focus-visible, a:focus-visible, input:focus-visible, select:focus-visible, [tabindex]:focus-visible { outline: 3px solid var(--accent); outline-offset: 3px; }
[hidden] { display: none !important; }
.site-header, main, footer { width: min(1540px, calc(100% - 48px)); margin-inline: auto; }
.site-header { display: flex; align-items: center; justify-content: space-between; gap: 20px; min-height: 86px; border-bottom: 1px solid var(--line); }
.brand { font: 700 33px Georgia, 'Times New Roman', serif; letter-spacing: -1px; color: var(--text); text-decoration: none; }
.brand:hover { text-decoration: none; }
.brand span { font: 400 13px Arial, Helvetica, sans-serif; letter-spacing: 1.5px; margin-left: 10px; color: var(--muted); }
.site-header nav { display: flex; align-items: center; gap: 24px; color: var(--muted); font-size: 15px; }
.site-header nav a { color: var(--muted); }
.site-header nav a:hover { color: var(--text); }
footer { border-top: 1px solid var(--line); display: flex; justify-content: space-between; align-items: center; gap: 20px; padding-block: 24px; margin-top: 44px; font-size: 14px; color: var(--muted); }
.skip-link { position: absolute; top: -80px; left: 24px; padding: 10px 16px; background: var(--accent); color: var(--bg); z-index: 100; }
.skip-link:focus { top: 10px; }
.gene-tools { display: flex; flex-wrap: wrap; gap: 6px 20px; padding-block: 16px; border-bottom: 1px solid var(--line); font-size: 12px; }
.gene-tools a { color: var(--muted); padding-block: 3px; }
.gene-tools a[aria-current] { color: var(--accent); text-decoration: underline; text-decoration-thickness: 2px; }
.page-top { padding-block: 26px 22px; border-bottom: 1px solid var(--line); margin-bottom: 22px; }
.catalog-meta { color: var(--muted); font-size: 12.5px; margin: 0 0 10px; font-variant-numeric: tabular-nums; }
h1 { font: 600 clamp(26px, 2.5vw, 35px)/1.2 Georgia, serif; margin: 0 0 8px; }
.lead { color: var(--muted); max-width: 1000px; font-size: 15px; margin: 0; }
h2 { font-size: 20px; line-height: 1.3; margin: 0; }
h3 { font-size: 15px; margin: 0 0 12px; }
p { margin: 0; }
.panel { min-width: 0; background: var(--panel); border: 1px solid var(--line); border-radius: 7px; padding: 22px; margin-bottom: 20px; }
.section-head { display: flex; gap: 16px; justify-content: space-between; align-items: flex-start; margin-bottom: 18px; }
.section-head p, .help { color: var(--muted); font-size: 12.5px; line-height: 1.55; margin-top: 5px; }
.btn-accent, .btn-secondary { display: inline-flex; align-items: center; justify-content: center; gap: 5px; border: 1px solid var(--line); border-radius: 4px; padding: 9px 13px; font-size: 13px; line-height: 1.35; min-height: 38px; background: var(--panel-deep); white-space: nowrap; }
.btn-accent { background: var(--accent); color: var(--panel-deep); border-color: var(--accent); font-weight: 700; }
.btn-secondary:hover:not(:disabled) { background: var(--panel-alt); border-color: var(--muted); }
.btn-accent:hover { background: #e4efc8; }
.loading-panel { padding: 28px; display: flex; align-items: center; gap: 16px; border: 1px solid var(--line); border-radius: 7px; background: var(--panel); }
.loading-panel p { color: var(--muted); margin-top: 4px; }
.spinner { width: 24px; height: 24px; flex-shrink: 0; border: 2px solid var(--line); border-top-color: var(--accent); border-radius: 50%; animation: spin .8s linear infinite; }
@keyframes spin { to { transform: rotate(360deg); } }
.search-panel { position: relative; z-index: 2; }
.search-modes { display: flex; gap: 4px; margin-bottom: 16px; border-bottom: 1px solid var(--line); }
.search-modes button { border: 0; border-bottom: 2px solid transparent; padding: 10px 14px; background: none; color: var(--muted); font-size: 13px; }
.search-modes button[aria-pressed="true"] { border-bottom-color: var(--accent); color: var(--text); }
.search-modes span { color: var(--muted); font-size: 11px; margin-left: 6px; }
.search-box { position: relative; }
.search-box > label, .field > span { display: block; color: var(--muted); font-size: 12px; margin-bottom: 6px; }
.search-input-row { display: flex; gap: 8px; }
input, select { border: 1px solid var(--line); background: var(--panel-deep); border-radius: 4px; min-width: 0; padding: 10px 12px; width: 100%; }
select { padding-right: 28px; }
input::placeholder { color: #839a9c; }
#catalogSearch { flex: 1; font-size: 17px; padding: 14px; }
#suggestions { position: absolute; left: 0; right: 0; top: 100%; margin: 5px 0 0; list-style: none; border: 1px solid #6d8587; background: var(--panel-deep); padding: 5px; border-radius: 5px; box-shadow: 0 14px 35px #0006; max-height: 390px; overflow-y: auto; z-index: 5; }
#suggestions li { padding: 10px 12px; cursor: pointer; border-radius: 3px; display: flex; justify-content: space-between; gap: 18px; border-bottom: 1px solid var(--line); }
#suggestions li:last-child { border-bottom: 0; }
#suggestions li[aria-selected="true"], #suggestions li:hover { background: var(--panel-alt); outline: 1px solid var(--accent); outline-offset: -1px; }
#suggestions small { display: block; color: var(--muted); font-size: 12px; margin-top: 2px; }
#suggestions .result-count { align-self: center; color: var(--muted); white-space: nowrap; font-size: 12px; }
#suggestions .no-result { cursor: default; color: var(--muted); }
.quick-genes { margin-top: 16px; padding-top: 15px; border-top: 1px solid var(--line); display: flex; align-items: flex-start; gap: 16px; }
.quick-genes > span { color: var(--muted); font-size: 12px; white-space: nowrap; padding-top: 5px; }
.quick-genes > div { display: flex; flex-wrap: wrap; gap: 5px; }
.gene-chip { background: var(--panel-deep); border: 1px solid var(--line); border-radius: 4px; padding: 4px 9px; font-size: 12px; color: var(--accent); }
.gene-chip:hover, .gene-chip[aria-pressed="true"] { border-color: var(--accent); background: var(--panel-alt); }
.dossier-grid { display: grid; grid-template-columns: minmax(260px,.85fr) minmax(0,1.65fr); gap: 20px; }
.identity-panel { border-top: 3px solid var(--accent); }
.section-label { font-size: 11px; color: var(--muted); letter-spacing: 1px; text-transform: uppercase; }
#geneSymbol { color: var(--accent); font: 600 clamp(32px, 4vw, 47px)/1.2 Georgia, serif; margin-top: 8px; overflow-wrap: anywhere; }
.gene-name { font-size: 17px; margin: 7px 0 20px; }
.identity-list { display: grid; grid-template-columns: 110px 1fr; gap: 7px 12px; font-size: 13px; margin-block: 15px; }
.identity-list dt { color: var(--muted); }
.identity-list dd { margin: 0; }
.reference-links { display: flex; gap: 18px; font-size: 12px; margin-top: 18px; }
.kpi-grid { display: grid; grid-template-columns: repeat(3,1fr); gap: 12px; margin: 25px 0; }
.kpi { background: var(--panel-deep); border: 1px solid var(--line); border-radius: 4px; padding: 18px 14px; min-width: 0; }
.kpi-label { color: var(--muted); font-size: 12px; }
.kpi-value { display: block; font-size: clamp(25px,2.5vw,35px); line-height: 1.3; font-variant-numeric: tabular-nums; margin: 5px 0; }
.kpi small { display: block; color: var(--muted); font-size: 12px; }
.strong-text { color: var(--strong); }
.weak-text { color: var(--weak); }
.stacked-bar { display: flex; overflow: hidden; height: 10px; background: #34464b; border-radius: 2px; min-width: 100px; }
.stacked-bar.big { height: 17px; }
.stacked-bar > span { min-width: 0; height: 100%; }
.strong { background: var(--strong); }
.weak { background: var(--weak); }
.absent { background: #44565c; }
.legend { display: flex; flex-wrap: wrap; gap: 16px; margin-block: 12px; color: var(--muted); font-size: 11px; }
.legend > span { display: inline-flex; align-items: center; gap: 6px; }
.swatch { display: inline-block; width: 9px; height: 9px; border-radius: 1px; }
.expression-summary { display: grid; grid-template-columns: 1.5fr 1.1fr .6fr 1fr; margin-bottom: 20px; border: 1px solid var(--line); background: var(--panel-deep); border-radius: 4px; }
.expression-stat { padding: 14px 16px; border-right: 1px solid var(--line); min-width: 0; }
.expression-stat:last-child { border-right: 0; }
.expression-stat span { display: block; color: var(--muted); font-size: 11px; margin-bottom: 5px; }
.expression-stat strong { font-size: 14px; }
.organ-grid { display: grid; grid-template-columns: repeat(4,1fr); gap: 8px; margin-bottom: 12px; }
.organ-tile { border: 1px solid var(--line); border-radius: 4px; background: var(--panel-deep); padding: 12px; min-height: 84px; }
.organ-tile.expressed { background: #67d49b0b; border-color: #527063; }
.organ-tile.primary { background: #d7e7a812; border-color: var(--accent); }
.organ-tile strong { display: block; font-size: 12px; }
.organ-tile span { display: block; color: var(--muted); font-size: 11px; margin-top: 6px; }
.organ-tile.expressed span { color: var(--strong); }
.organ-tile.primary span { color: var(--accent); }
.annotation-grid { display: grid; grid-template-columns: 1fr 1fr; gap: 20px; }
.membership-list { display: grid; gap: 7px; }
.membership-btn { text-align: left; border: 1px solid var(--line); border-radius: 4px; background: var(--panel-deep); padding: 11px 13px; width: 100%; font-size: 12px; }
.membership-btn:hover { border-color: var(--accent); }
.membership-btn strong { color: var(--accent); display: block; font-size: 13px; }
.membership-btn small { color: var(--muted); display: block; margin-top: 4px; }
.go-group + .go-group { margin-top: 17px; }
.go-group h3 { color: var(--muted); font-size: 11px; text-transform: uppercase; letter-spacing: .7px; margin-bottom: 7px; }
.go-links { display: flex; flex-wrap: wrap; gap: 6px; }
.go-term { padding: 6px 9px; color: var(--accent); border: 1px solid var(--line); border-radius: 4px; background: var(--panel-deep); text-align: left; font-size: 11px; }
.go-term:hover { border-color: var(--accent); }
.table-scroll { overflow: auto; border: 1px solid var(--line); border-radius: 4px; }
.data-table { width: 100%; border-collapse: collapse; text-align: left; font-size: 12px; }
.data-table th { background: var(--panel-deep); color: var(--muted); font-weight: 400; padding: 11px 12px; border-bottom: 1px solid var(--line); position: sticky; top: 0; z-index: 1; }
.data-table td { padding: 10px 12px; border-bottom: 1px solid var(--line); font-variant-numeric: tabular-nums; vertical-align: middle; }
.data-table tr:last-child td { border-bottom: 0; }
.data-table tbody tr:hover { background: var(--panel-alt); }
.data-table td small { color: var(--muted); display: block; font-size: 11px; margin-top: 2px; }
.breakdown-table { min-width: 830px; }
.breakdown-table td:nth-child(1) { width: 27%; }
.breakdown-table td:nth-child(3) { width: 23%; }
.breakdown-table td:nth-child(n+4) { white-space: nowrap; }
.breakdown-table td:nth-child(4) { color: var(--strong); }
.breakdown-table td:nth-child(5) { color: var(--weak); }
.breakdown-table td:nth-child(6) { color: var(--muted); }
.subsection-heading { margin-top: 26px; }
.group-scroll { max-height: 530px; }
.species-filters { display: grid; grid-template-columns: minmax(230px,1.7fr) repeat(4,minmax(120px,1fr)); gap: 10px; margin-bottom: 16px; }
.field { display: block; min-width: 0; }
.field input, .field select { font-size: 12px; min-height: 39px; }
.species-table { min-width: 850px; }
.species-table td:first-child { min-width: 230px; }
.status-word { white-space: nowrap; }
.status-word.strong-text::before, .status-word.weak-text::before { content: ''; display: inline-block; border-radius: 50%; background: currentColor; width: 5px; height: 5px; margin-right: 6px; vertical-align: middle; }
.status-word.absent-text { color: var(--muted); }
.pagination { display: flex; align-items: center; justify-content: space-between; gap: 12px; margin-top: 15px; color: var(--muted); font-size: 12px; }
.pagination > div { display: flex; gap: 7px; }
.empty-cell { padding: 32px !important; color: var(--muted); text-align: center; }
.data-note { font-size: 12px; color: var(--muted); max-width: 1100px; margin: 8px 0; }
.drawer-backdrop { position: fixed; inset: 0; background: #05090db8; z-index: 50; display: flex; justify-content: flex-end; }
.finder-drawer { width: min(950px,100%); max-height: 100dvh; height: 100%; background: var(--bg); border-left: 1px solid var(--line); box-shadow: -10px 0 45px #0004; display: flex; flex-direction: column; }
.drawer-header { padding: 23px 26px; border-bottom: 1px solid var(--line); display: flex; align-items: flex-start; justify-content: space-between; gap: 16px; background: var(--panel); }
.drawer-header p { margin-top: 5px; color: var(--muted); font-size: 12px; }
.drawer-body { padding: 23px 26px; overflow: auto; }
.finder-filters { display: grid; grid-template-columns: 1fr 1fr; gap: 13px; }
.finder-filters .wide { grid-column: 1 / -1; }
.check-field { display: flex; align-items: flex-start; gap: 9px; margin: 17px 0 8px; font-size: 12px; }
.check-field input { width: 16px; height: 16px; padding: 0; flex-shrink: 0; accent-color: var(--accent); margin: 1px 0 0; }
.finder-actions { display: flex; gap: 8px; flex-wrap: wrap; margin-top: 17px; }
.finder-results-head { margin-top: 25px; padding-top: 18px; border-top: 1px solid var(--line); align-items: center; font-size: 12px; color: var(--muted); }
.finder-results-head h3 { margin: 0; color: var(--text); }
.finder-table { min-width: 620px; }
.gene-result { background: none; border: 0; color: var(--accent); padding: 0; font-weight: 700; text-align: left; }
.gene-result:hover { text-decoration: underline; }
.finder-table td:first-child { max-width: 250px; }
.finder-table td:first-child small { max-width: 230px; }
.drawer-open { overflow: hidden; }
@media (max-width: 1050px) {
  .site-header nav { gap: 16px; }
  .dossier-grid { grid-template-columns: 1fr 1.5fr; }
  .kpi-grid { gap: 6px; }
  .kpi { padding: 13px 10px; }
  .organ-grid { grid-template-columns: repeat(4,1fr); }
  .species-filters { grid-template-columns: repeat(4,1fr); }
  .species-filters .search-field { grid-column: 1 / -1; }
  .expression-summary { grid-template-columns: 1fr 1fr; }
  .expression-stat:nth-child(2) { border-right: 0; }
  .expression-stat:nth-child(-n+2) { border-bottom: 1px solid var(--line); }
}
@media (max-width: 740px) {
  .site-header, main, footer { width: calc(100% - 28px); }
  .site-header { flex-wrap: wrap; padding-block: 14px; gap: 10px; }
  .brand { font-size: 28px; }
  .site-header nav { gap: 18px; font-size: 12px; }
  .gene-tools { gap: 6px 15px; font-size: 11px; }
  .page-top { padding-block: 22px; }
  .panel { padding: 17px; }
  .section-head { flex-wrap: wrap; }
  .search-modes button { padding: 10px 8px; font-size: 12px; }
  .search-modes span { font-size: 10px; margin-left: 3px; }
  .quick-genes { flex-direction: column; gap: 8px; }
  .dossier-grid, .annotation-grid { grid-template-columns: 1fr; gap: 0; }
  .organ-grid { grid-template-columns: repeat(2,1fr); }
  .expression-summary { grid-template-columns: 1fr 1fr; }
  .expression-stat { padding: 12px; }
  .species-filters { grid-template-columns: 1fr 1fr; }
  .pagination { align-items: flex-start; flex-wrap: wrap; }
  .drawer-header, .drawer-body { padding: 18px; }
  footer { align-items: flex-start; font-size: 12px; }
}
@media (prefers-reduced-motion: reduce) { .spinner { animation: none; } }