:root{color-scheme:dark;--bg:#141c25;--panel:#1c2833;--panel-alt:#213035;--panel-deep:#10171f;--text:#f1f1e6;--muted:#b8cccb;--line:#34464b;--accent:#d7e7a8;--strong:#67d49b;--weak:#e8b85c;font-family:Arial,Helvetica,sans-serif}
*{box-sizing:border-box}body{margin:0;background:var(--bg);color:var(--text);min-height:100svh;font-size:15px;line-height:1.5}a{color:var(--accent);text-decoration:none;text-underline-offset:4px}a:hover{text-decoration:underline}button,input,select{font:inherit;color:inherit}button{cursor:pointer}button:disabled{opacity:.4;cursor:default}button:focus-visible,a:focus-visible,input:focus-visible,select:focus-visible,summary:focus-visible,[tabindex]:focus-visible{outline:3px solid var(--accent);outline-offset:3px}[hidden]{display:none!important}
.site-header,main,footer{width:min(1540px,calc(100% - 48px));margin-inline:auto}.site-header{display:flex;align-items:center;justify-content:space-between;gap:20px;min-height:86px;border-bottom:1px solid var(--line)}.brand{font:700 33px Georgia,'Times New Roman',serif;letter-spacing:-1px;color:var(--text);text-decoration:none}.brand:hover{text-decoration:none}.brand span{font:400 13px Arial,Helvetica,sans-serif;letter-spacing:1.5px;margin-left:10px;color:var(--muted)}.site-header nav{display:flex;align-items:center;gap:24px;color:var(--muted);font-size:15px}.site-header nav a{color:var(--muted)}.site-header nav a:hover{color:var(--text)}footer{border-top:1px solid var(--line);display:flex;justify-content:space-between;align-items:center;gap:20px;padding-block:24px;margin-top:44px;font-size:14px;color:var(--muted)}
.page-top{display:flex;justify-content:space-between;align-items:flex-start;gap:28px;padding-block:26px 22px;border-bottom:1px solid var(--line);margin-bottom:18px}.page-top h1{font:600 clamp(26px,2.5vw,35px)/1.2 Georgia,serif;margin:0 0 8px}.lead{color:var(--muted);font-size:15px;max-width:1000px;margin:0}.page-reference{min-width:205px;padding:12px 16px;border-left:2px solid var(--line);font-size:13px}.page-reference span{color:var(--muted);font-size:12px}.gene-nav{display:flex;flex-wrap:wrap;gap:8px 20px;margin:0 0 22px;padding-bottom:18px;border-bottom:1px solid var(--line);font-size:13px}.gene-nav a{color:var(--muted)}.gene-nav [aria-current]{color:var(--accent);text-decoration:underline;text-decoration-thickness:2px}
.loading-panel{display:flex;align-items:center;gap:16px;padding:26px;background:var(--panel);border:1px solid var(--line);border-radius:7px;margin:24px 0}.loading-panel p{margin:5px 0 0;color:var(--muted)}.spinner{width:25px;height:25px;border:3px solid var(--line);border-top-color:var(--accent);border-radius:50%;animation:spin 1s linear infinite;flex-shrink:0}@keyframes spin{to{transform:rotate(360deg)}}@media(prefers-reduced-motion:reduce){.spinner{animation:none}}
.panel{padding:22px;background:var(--panel);border:1px solid var(--line);border-radius:7px;margin-bottom:22px;min-width:0}.panel-header{display:flex;align-items:center;justify-content:space-between;gap:16px;margin-bottom:16px}.panel-header h2,h2{font-size:20px;font-weight:600;line-height:1.25;margin:0}.panel-header .note{margin-top:5px}.muted,.note{color:var(--muted)}.note{font-size:12.5px;line-height:1.5;margin:8px 0 0}.selection-grid{display:grid;grid-template-columns:.75fr 1fr 1.2fr;gap:16px}.control-field{display:flex;flex-direction:column;gap:6px;min-width:0}.control-field>span{font-size:12px;font-weight:600;color:var(--muted)}input,select{width:100%;min-height:42px;border:1px solid var(--line);border-radius:5px;background:var(--panel-deep);padding:8px 11px}select{padding-right:25px;text-overflow:ellipsis}input::placeholder{color:var(--muted);opacity:.7}button{border:1px solid var(--line);border-radius:5px;background:var(--panel-alt);padding:7px 12px}button:hover:not(:disabled){border-color:var(--accent)}.text-button{color:var(--accent);background:transparent}.quick-picks{display:flex;flex-wrap:wrap;gap:8px;margin-top:15px}.quick-picks button{font-size:12px;padding:5px 10px}.quick-picks button[aria-pressed=true]{border-color:var(--accent);color:var(--accent)}.metric-control{min-width:285px}
.karyotype-scroll{overflow-x:auto;padding:8px 0 3px}.karyotype{display:grid;grid-template-columns:repeat(25,minmax(36px,1fr));gap:7px;min-width:1050px}.chromosome-bar{display:flex;align-items:center;flex-direction:column;justify-content:flex-end;background:var(--panel-deep);padding:10px 3px 7px;min-width:0;border-color:transparent;position:relative}.chromosome-bar[aria-pressed=true]{border-color:var(--accent);background:var(--panel-alt)}.chromosome-bar .bar-area{display:flex;align-items:center;justify-content:flex-end;flex-direction:column;height:205px;width:100%;margin-bottom:9px}.ideogram{width:20px;min-height:2px;position:relative;border-radius:9px;background:var(--chrom-color);box-shadow:inset -4px 0 rgba(16,23,31,.22);overflow:hidden}.ideogram::after{content:"";position:absolute;top:var(--centromere);height:7px;left:0;right:0;background:var(--panel-deep);clip-path:polygon(0 0,35% 48%,0 100%,100% 100%,65% 48%,100% 0);transform:translateY(-50%)}.ideogram.mt{border-radius:50%;width:20px}.ideogram.mt::after{display:none}.chr-label{font-weight:700;font-size:13px}.chr-value{font-size:10px;color:var(--muted);white-space:nowrap;font-variant-numeric:tabular-nums}.chart-scale{display:flex;justify-content:space-between;color:var(--muted);font-size:12px;margin:12px 0}.chart-scale>span:first-child{display:flex;align-items:center;gap:8px}.scale-gradient{display:inline-block;width:110px;height:9px;background:linear-gradient(to right,var(--line),var(--strong));border-radius:2px}
.summary-section{margin-bottom:22px}.section-heading{display:flex;align-items:baseline;justify-content:space-between;gap:12px;margin-bottom:13px}.section-heading .muted{font-size:13px}.summary-grid{display:grid;grid-template-columns:repeat(5,1fr);gap:12px}.summary-card{padding:17px 18px;border:1px solid var(--line);background:var(--panel);border-radius:6px;min-width:0}.summary-card .label{display:block;color:var(--muted);font-size:12px}.summary-card .value{display:block;font-size:27px;line-height:1.35;font-weight:600;font-variant-numeric:tabular-nums;margin:7px 0 3px}.summary-card small{font-size:12px;color:var(--muted);display:block}.summary-card strong{color:var(--strong)}.summary-card .weak-text{color:var(--weak)}.summary-match{display:flex;gap:10px;align-items:baseline;flex-wrap:wrap;font-size:20px;margin:7px 0}.breakdown-grid{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:18px}.breakdown-grid .panel{padding:19px;margin-bottom:22px}.bar-list{display:grid;gap:7px;margin-top:14px}.bar-button{position:relative;display:grid;grid-template-columns:minmax(0,1fr) auto;gap:10px;text-align:left;width:100%;font-size:12px;line-height:1.35;padding:8px 9px;overflow:hidden;background:var(--panel-deep)}.bar-button::before{content:"";position:absolute;left:0;top:0;bottom:0;width:var(--fill);background:rgba(103,212,155,.1);pointer-events:none}.bar-button>span{position:relative}.bar-button>span:first-child{overflow:hidden;text-overflow:ellipsis;white-space:nowrap}.bar-button>span:last-child{color:var(--accent);font-variant-numeric:tabular-nums}.bar-button[aria-pressed=true]{border-color:var(--accent)}
.gene-filters{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:14px}.filter-summary{font-size:13px;color:var(--accent);margin:17px 0}.track-header{display:flex;align-items:flex-start;justify-content:space-between;gap:20px;padding-top:19px;border-top:1px solid var(--line)}h3{font-size:16px;font-weight:600;margin:0 0 10px}.track-header .note{max-width:750px}.track-controls{display:flex;gap:12px;min-width:320px}.track-controls label{flex:1}.legend{display:flex;flex-wrap:wrap;gap:8px 16px;font-size:11px;margin:14px 0 10px;color:var(--muted)}.legend-item{display:inline-flex;align-items:center;gap:6px}.swatch{width:9px;height:9px;display:inline-block;border:1px solid rgba(241,241,230,.2);border-radius:2px;background:var(--swatch)}.track-holder{position:relative;background:var(--panel-deep);border:1px solid var(--line);border-radius:5px;padding:10px;min-height:60px}canvas{display:block;width:100%;cursor:crosshair}.track-tooltip{position:absolute;top:6px;right:8px;max-width:90%;pointer-events:none;background:var(--bg);border:1px solid var(--accent);border-radius:4px;padding:7px 10px;font-size:12px;box-shadow:0 4px 16px rgba(0,0,0,.3)}.track-active{font-size:12px;min-height:20px;color:var(--accent);margin:4px 0 15px}.pagination{display:flex;justify-content:space-between;align-items:center;gap:12px;padding-top:12px;color:var(--muted);font-size:12px}.pagination>div{display:flex;gap:8px}.pagination button{font-size:12px}.table-toolbar{display:flex;align-items:center;justify-content:space-between;gap:15px;padding:20px 0 15px;border-top:1px solid var(--line)}.table-toolbar h3{margin:0}.table-options{display:flex;gap:12px}.table-options select{min-width:125px}.table-scroll{overflow:auto;border:1px solid var(--line);border-radius:5px}table{width:100%;border-collapse:collapse;text-align:left;font-size:12px}thead{background:var(--panel-deep)}th{font-size:11px;font-weight:600;color:var(--muted);padding:11px 12px;white-space:nowrap}td{border-top:1px solid var(--line);padding:10px 12px;vertical-align:top}tbody tr:hover{background:var(--panel-alt)}td:nth-child(2){min-width:200px;max-width:290px}td .gene-name{display:block;max-width:240px}td small{display:block;color:var(--muted);font-size:11px}td .number{font-variant-numeric:tabular-nums}td .family-label{display:block;max-width:180px;line-height:1.35}.gene-button,.chr-button{background:transparent;border:0;padding:0;color:var(--accent);font-weight:600;text-align:left}.gene-button:hover,.chr-button:hover{text-decoration:underline}.status{white-space:nowrap;font-size:11px;display:inline-flex;align-items:center;gap:5px}.status::before{content:"";width:6px;height:6px;border-radius:50%;background:var(--muted)}.status.strong{color:var(--strong)}.status.strong::before{background:var(--strong)}.status.weak{color:var(--weak)}.status.weak::before{background:var(--weak)}.status.absent{color:var(--muted)}.empty-state{padding:30px!important;text-align:center;color:var(--muted)}.method-note{max-width:1100px;color:var(--muted);font-size:13px}.method-note h2{font-size:18px;color:var(--text);margin-bottom:10px}.method-note p{margin:9px 0}
dialog{color:var(--text);background:var(--bg);border:1px solid var(--line);border-radius:9px;width:min(1120px,calc(100% - 32px));max-height:90svh;padding:0}dialog::backdrop{background:rgba(0,0,0,.72)}.dialog-header{position:sticky;top:0;display:flex;align-items:flex-start;justify-content:space-between;gap:18px;padding:20px 24px;background:var(--panel);border-bottom:1px solid var(--line);z-index:2}.dialog-header h2{font:600 27px/1.2 Georgia,serif}.dialog-header p{margin:5px 0 0}.dialog-body{padding:22px 24px}.dialog-meta{display:flex;flex-wrap:wrap;gap:13px 25px;font-size:13px;margin-bottom:16px}.dialog-link{display:inline-block;margin:0 0 18px}.annotation-section{padding:14px;background:var(--panel);border:1px solid var(--line);border-radius:5px;margin-bottom:12px}.annotation-section h3{font-size:14px}.annotation-section p{font-size:13px;color:var(--muted);margin:7px 0}.annotation-buttons{display:flex;flex-wrap:wrap;gap:7px}.annotation-buttons button{font-size:12px;text-align:left}.organ-tags{display:flex;flex-wrap:wrap;gap:6px}.organ-tag{border:1px solid var(--line);padding:4px 7px;border-radius:4px;font-size:11px;color:var(--muted);opacity:.65}.organ-tag.expressed{color:var(--text);background:var(--panel-alt);opacity:1}.organ-tag.primary{border-color:var(--accent);color:var(--accent)}.dialog-grid{display:grid;grid-template-columns:1fr 1fr;gap:22px;margin:24px 0}.dialog-groups{max-height:350px;overflow:auto;padding-right:6px}.presence-row{font-size:11px;margin:0 0 10px}.presence-label{display:flex;justify-content:space-between;gap:8px;margin-bottom:4px;color:var(--muted)}.presence-track{height:7px;display:flex;background:var(--line);border-radius:2px;overflow:hidden}.presence-strong{background:var(--strong)}.presence-weak{background:var(--weak)}.dialog-species-heading{display:grid;grid-template-columns:1fr 1.2fr .8fr;align-items:end;gap:15px;margin:15px 0}.dialog-species-heading h3{margin:0 0 10px}
@media(max-width:1150px){.summary-grid{grid-template-columns:repeat(3,1fr)}.breakdown-grid{gap:12px}.breakdown-grid .panel{padding:14px}.track-header{display:block}.track-controls{margin-top:14px;max-width:520px}.page-reference{display:none}}
@media(max-width:780px){.site-header,main,footer{width:calc(100% - 28px)}.site-header{flex-wrap:wrap;gap:10px;padding:16px 0}.brand{font-size:29px}.brand span{font-size:11px}.site-header nav{gap:18px;font-size:13px}.page-top{padding-top:22px}.page-top h1{font-size:29px}.gene-nav{gap:10px 16px}.panel{padding:17px}.selection-grid{grid-template-columns:1fr 1fr}.selection-grid>label:first-child{grid-column:1/-1}.panel-header{align-items:flex-start;flex-wrap:wrap}.metric-control{min-width:0;width:100%}.breakdown-grid{grid-template-columns:1fr}.breakdown-grid .panel{padding:17px;margin-bottom:0}.breakdown-grid{margin-bottom:22px}.bar-list{grid-template-columns:1fr 1fr}.summary-grid{grid-template-columns:repeat(2,1fr)}.section-heading{align-items:flex-start;flex-direction:column;gap:4px}.gene-filters{grid-template-columns:1fr 1fr}.summary-card .value{font-size:25px}.table-toolbar{align-items:flex-start;flex-direction:column}.table-options{width:100%}.table-options label:first-child{flex:1}.dialog-body{padding:18px}.dialog-header{padding:17px 18px}.dialog-grid{grid-template-columns:1fr}.dialog-species-heading{grid-template-columns:1fr 1fr}.dialog-species-heading h3{grid-column:1/-1}.pagination{flex-wrap:wrap}.chart-scale{gap:12px;flex-wrap:wrap}footer{align-items:flex-start;font-size:12px}}
@media(max-width:480px){.selection-grid,.gene-filters{grid-template-columns:1fr}.selection-grid>label:first-child{grid-column:auto}.bar-list{grid-template-columns:1fr}.summary-card{padding:13px}.summary-card .value{font-size:23px}.track-controls{min-width:0;width:100%}.track-controls select{font-size:12px}.table-options select{font-size:12px;min-width:90px}.page-top h1{font-size:27px}.brand span{margin-left:6px}.dialog-species-heading{grid-template-columns:1fr}.dialog-species-heading h3{grid-column:auto}.panel-header h2,h2{font-size:18px}}